Cytovance® Biologics is a biopharmaceutical contract manufacturing company specializing in the production of therapeutic proteins and antibodies from mammalian cell culture, microbial fermentation, and flex suite platforms.
Cytovance® Biologics was founded in 2003 based on the client-side experiences of the executive team of Novazyme Pharmaceuticals. In order to develop alpha glucosidase and other recombinant enzyme replacement therapies it was necessary to access, contract with and manage numerous service providers. These included contract manufacturers, companies and consultants providing cell banking, analytical development and testing services, fill/finish, validation and numerous ancillary services.
In addition to its cGMP manufacturing services, the company offers process development, cGMP cell banking and support services from its state-of-the-art facilities. Cytovance adds significant value to biopharmaceutical development programs by helping companies advance recombinant proteins, antibodies, and cell-based therapeutic products rapidly and cost-effectively from the laboratory bench, through clinical development and to commercial launch in international markets.
Major Markets: Cytovance Biologics serves Biotech and Pharmaceutical industries globally. Development Services include: Cell Line Development, Microbial Strain Development, Microbial and Mammalian Process Development, Pre-formulation Studies, Analytical Method Development, Qualification and Validation and Process Characterization. cGMP Manufacturing includes cell banking (microbial and mammalian) Cell Culture production from 50L-2,000L, Microbial Manufacturing up to 200L - 1000L , Process Validation and Commercial Drug Substance Manufacturing, Automated Vial Fill/Finish. Support Services include: Project Management, Raw Material Management, QC testing and ICH Stability Studies.
Cytovance operates from several facilities in Oklahoma City, Oklahoma. With over 140,000 sq. ft. of multi-product GMP manufacturing capacity designed to meet U.S., EU, and other global regulatory standards. This facility features primary production in cell culture suites featuring single-use bioreactors at 50L, 100L, 250L, 1,000L and 2,000L scales. Stainless Steel bioreactors at 100Land 500L scales. Segregated microbial production at 200L, 300L and 1000L scales. Refolding of microbial oroteins at 2 X 5000L scale. Recovery and purification is undertaken in adjacent independent suites. In addition, Cytovance cGMP “Flex Processing Suites” suitable for pilot production, small scale production, alternative promotion platforms and immunotherapy
Cytovance® Biologics facilities are located in Oklahoma City, Oklahoma. Each is designed to meet global regulatory standards. At Cytovance, we place significant value on customer service through our culture of responsibility and reliability.