Better health outcomes, strategies to decrease overall cost of healthcare, and insights coming from basic and translational research are drivers shaping the field of precision medicine. Multi-omic technologies are accelerating the path of discovery, diagnosis and treatment, and are being deployed with large scale clinical utility. In this session we will present large-scale programs aimed at screening healthy populations for genetic and biochemical risk factors which are actionable. Three unique approaches will be discussed: (1) genetic screening of couples to help them assess the risk of rare disease in their children, (2) genetic screening of individuals to assess potential resistance or hypersensitivity to medications, and (3) metabolic screening of individuals to detect imbalances that could indicate underlying disease. These case studies will also exemplify the need for collaborations to successfully design, implement, adopt, and scale the work regionally and globally.

Session ID: 361813